2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Chloride Channel

Chloride Channel

Cl− Channels

Chloride Channel

Related Products

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Chloride channels belong to a superfamily of ion channels that permit passive passage of anions, mainly chloride, across cell membrane. Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. Chloride channels represent a group of potential drug targets.

The chloride channel protein (ClC) family comprises both chloride (Cl-) channels and chloride/proton (Cl-/H+) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl- ions across the membrane. In eukaryotes, ClC proteins play a role in the stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity and vesicular acidification.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105917
    Emidurdar
    		Inhibitor 99.41%
    Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor.
    Emidurdar
  • HY-146334
    DFBTA
    		Inhibitor 99.25%
    DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. DFBTA shows analgesic efficacy for inflammatory pain.
    DFBTA
  • HY-146320
    ANO1-IN-1
    		Inhibitor 99.57%
    ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells.
    ANO1-IN-1
  • HY-103370
    Talniflumate
    		Inhibitor 99.67%
    Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase. Talniflumate is an orally active Ca2+-activated Cl- channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome.
    Talniflumate
  • HY-18996
    Adjudin
    		Inhibitor ≥98.0%
    Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect. Adjudin is also a potent Cl- channel blocker.
    Adjudin
  • HY-154912
    PAT1inh-B01
    		Inhibitor 98.32%
    PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders.
    PAT1inh-B01
  • HY-P0173B
    Chlorotoxin TFA
    		Inhibitor 98.46%
    Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker. Anti-cancer activity.
    Chlorotoxin TFA
  • HY-101329
    Anthracene-9-carboxylic acid
    		Inhibitor 99.09%
    Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.
    Anthracene-9-carboxylic acid
  • HY-154912A
    PAT1inh-B01 hydrochloride
    		Inhibitor ≥98.0%
    PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders.
    PAT1inh-B01 hydrochloride
  • HY-N2412
    Irisolidone
    		Inhibitor 99.66%
    Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC50=9.8 μM).
    Irisolidone
  • HY-B0908
    Meticrane
    		Inhibitor 98.54%
    Meticrane is a diuretic. Meticrane inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
    Meticrane
  • HY-100613
    MONNA
    		Inhibitor 99.79%
    MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
    MONNA
  • HY-158183
    NMD670
    		Inhibitor 99.60%
    NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue.
    NMD670
  • HY-W040265
    Fenamic acid
    		Inhibitor 98.19%
    Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent-.
    Fenamic acid
  • HY-W011240
    Hydroflumethiazide
    		99.25%
    Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas.
    Hydroflumethiazide
  • HY-137148
    DIOA
    		Antagonist 99.1%
    DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist.
    DIOA
  • HY-163171
    ARN11391
    		99.4%
    ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia.
    ARN11391
  • HY-P1105
    GaTx2
    		98.00%
    GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types.
    GaTx2
  • HY-A0234
    Stepronin
    		Inhibitor 99.93%
    Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.
    Stepronin
  • HY-118170
    T16A(inh)-C01
    		Inhibitor
    T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling.
    T16A(inh)-C01
Cat. No. Product Name / Synonyms Application Reactivity